Two postdoc positions in experimental hematology to study normal and malignant hematopoietic stem cell biology

The Porse group at the Finsen Laboratory/BRIC at University of Copenhagen is seeking two highly motivated postdocs to work on hematopoietic stem cell biology. Our research/The group The Porse group (Finsen Laboratory/BRIC) has a diverse and stimulating environment and we focus our research on elucidating mechanisms governing normal and malignant haematopoiesis with special emphasis on the behaviour of hematopoietic stem cells (HSCs) during adult haematopoiesis and leukemic stem cells (LSCs) in acute myeloid leukaemia. To this end, we employ mouse models of human AML, mouse knockout lines of putative HSC/LSC regulators, primary patient material and a broad range of genome-wide approaches and single cell analyses incl. cutting edge single cell proteomics. The Porse group is affiliated with the Finsen Laboratory at Rigshospitalet as well as with BRIC at the University of Copenhagen. Project/The research project(s) The successful candidate will join an international and interdisciplinary research group working on various aspects of normal and malignant hematopoietic stem cell biology including associated diseases such as acute myeloid leukemia. The candidate(s) will use advanced CRISPR-Cas9 gene editing technologies in primary human material to functionally assess novel regulators of normal and malignant hematopoietic stem cell biology. These regulators were identified by advanced proteomics technologies and their expression patterns are to a large degree governed by non-transcriptional mechanisms. There will be a large degree of freedom for the candidate(s) to shape and drive the research projects forward. Start: 1 November 2023 or as soon as possible Duration: 3 years (with possible extension based on performance) Qualifications We expect you to be a highly motivated and highly ambitious scientist with the following qualifications:

• A PhD in life sciences or equivalent research experience.
• Strong documented research experience and expertise in either single-cell. technologies, experimental mouse work, biochemistry, advanced flow cytometry, genome-wide approaches (ChIP-seq, Chromatin Conformation Capture, etc), CRISPR technologies or functional haematopoiesis.
• Candidates with combined experiences are particularly encouraged to apply.
• Good organizational skills and a detail-oriented structured approach to work tasks.
• Collaborative skills.
• Excellent English skills written and spoken.

For further information regarding the position, please contact Professor Bo Porse on e-mail: bo.porse@finsenlab.dk Place of employment The employment is at BRIC, University of Copenhagen. BRIC is located in the Biocenter, close to the centre of Copenhagen. We offer creative and stimulating working conditions in a dynamic and international research environment. Our research facilities include modern laboratories and several core facilities (NGS, single cell and spatial aspects, high-throughput robotics tec.) shared between the 26 research groups at BRIC and the neighboring Finsen Laboratory. We have weekly journal clubs, data clubs, seminars with invited international speakers. A young researchers club (ASAP), our own PhD programme (MoMeD) and our own Postdoc Career Programme . BRIC actively participates in the European alliance, EU-life consisting of 13 excellent life science research institutions http://eu-life.eu/ Please read more about the Andersen group and BRIC research on http://www.bric.ku.dk/ Terms of salary and employment Salary, pension and terms of employment will be in accordance with the agreement between the Ministry of Finance and The Academics Central organization. Currently, the monthly salary starts at 38,500 DKK/ approx. 5,100 EUR (April 2024 level). Depending on qualifications, a supplement may be negotiated. The employer will pay an additional 17.1 % to your pension fund. Non-Danish and Danish applicants may be eligible for tax reductions, if they hold a PhD degree and have not lived in Denmark the last 10 years. The position is covered by the Job Structure for Academic Staff at Universities 2020. Application Your application must be submitted electronically by clicking ‘Apply now’ below or via BRIC’s website on http://www.bric.ku.dk/jobs/ . The application must include the following documents/attachments – all in PDF format:

• Motivated letter of application (max. one page).

• CV incl. education, work/research experience, language skills and other skills relevant for the position.

• A certified/signed copy of a) PhD certificate and b) Master of Science certificate. If the PhD is not completed, a written statement from the supervisor will do.

• List of publications.

Letters of recommendation Furthermore, the applicant should provide two letters of recommendation. To be taken into consideration, the letter must be signed by the supporting person on paper with institutional letter head and in PDF-format. The letters should be received before deadline on bo.porse@finsenlab.dk preferably by the supporting person. Please make sure that an easy match between the recommendation letter and the individual applicant is possible. Application deadline: 30 June 2024, 23.59pm CET We reserve the right not to consider material received after the deadline, and not to consider applications or letters of recommendation that do not live up to the above-mentioned requirements. The further process After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the hiring committee. All applicants are then immediately notified whether their application has been passed for assessment by an unbiased assessor. Once the assessment work has been completed each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself. You can read about the recruitment process at http://employment.ku.dk/faculty/recruitment-process/ The applicant will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities. BRIC and University of Copenhagen wish to reflect the diversity of society and welcome applications from all qualified candidates regardless of personal background.